The league removed Aiyuk from the reserve/left squad list on Monday and gave the 49ers a two-week exemption before they need to add him to the 53-man roster.
Arizona Cardinals wide receiver Michael Wilson is out for the year because of a fracture in his neck, and QB Gardner Minshew's season may also be over.
Games featuring two Big Ten teams have averaged 47.3 total points this season, putting the league on pace for its lowest season-ending average since 2023.
