WIMBLEDON, England (AP) — The Latest from Wimbledon (all times local):

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9:30 p.m.

Two-time champion Andy Murray’s second-round loss to John Isner is his earliest exit from Wimbledon.

The 6-foot-10 American beat Murray 6-4, 7-6 (4), 6-7 (3), 6-4, hitting 36 aces and 82 winners.

Murray had never lost before the third round at the All England Club. The 35-year-old Scot won the Wimbledon title in 2013 and 2016.

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8:40 p.m.

Fifth-seeded Carlos Alcaraz advanced to the third round at Wimbledon with a 6-4, 7-6 (0), 6-3 victory over Tallon Griekspoor of the Netherlands.

The win keeps the 19-year-old Spaniard on course for a potential quarterfinal match against top-ranked Novak Djokovic.

Alcaraz will next play the 32nd-seeded Oscar Otte of Germany.

Tenth-seeded Jannik Sinner of Italy beat Mikael Ymer of Sweden 6-4, 6-3, 5-7, 6-2 to reach the third round, where he’ll play either Andy Murray or John Isner.

In the women’s draw, third-seeded Ons Jabeur beat Katarzyna Kawa 6-4, 6-0 to set up a third-round match against Diane Parry of France.

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5:30 p.m.

Emma Raducanu is out of Wimbledon in the second round after losing to Caroline Garcia 6-3, 6-3 on Centre Court.

The 19-year-old Raducanu is the reigning U.S. Open champion but she ran into a player on a roll. The 28-year-old Frenchwoman won her seventh consecutive match.

Garcia won the Bad Homburg title in Germany last week for her first title in three years.

The 10th-seeded Raducanu reached the fourth round last year at the All England Club as a wild-card entry at the age of 18.

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4:20 p.m.

Two-time Grand Slam champion Garbine Muguruza lost in the first round of Wimbledon to Greet Minnen of Belgium 6-4, 6-0.

The 2017 Wimbledon champion, who is seeded ninth, made 33 unforced errors and hit only nine winners on No. 2 Court.

In another delayed first-round match, eighth-seeded Jessica Pegula of the United States beat Croatian player Donna Vekic 6-3, 7-6 (2).

And 12th-seeded Jelena Ostapenko defeated Yanina Wickmayer of Belgium 6-2, 6-2 to reach the third round. The Latvian won the 2017 French Open and was Wimbledon runner-up in 2018.

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3:50 p.m.

Top-seeded Novak Djokovic advanced to the third round at Wimbledon with a 6-1, 6-4, 6-2 victory over Thanasi Kokkinakis of Australia.

The six-time Wimbledon champion has won the past three men’s singles titles at the All England Club.

The 26-year-old Kokkinakis is ranked 79th.

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3:35 p.m.

French Open runner-up Casper Ruud lost in the second round at Wimbledon.

The third-seeded Norwegian was beaten by Ugo Humbert of France 3-6, 6-2, 7-5, 6-4 on No. 2 Court.

Ruud was making his third appearance at the All England Club. His victory over Albert Ramos-Vinolas on Monday was his first at the grass-court Grand Slam.

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2:25 p.m.

Second-seeded Anett Kontaveit of Estonia was eliminated in the second round of Wimbledon, losing to Jule Niemeier of Germany 6-4, 6-0.

Kontaveit has never reached the fourth round at the All England Club, the only one of the four major tournaments in which she has failed to get that far. She was making her eighth appearance at Wimbledon.

It was Kontaveit’s first match on grass this year.

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2:15 p.m.

Harmony Tan, who beat Serena Williams on Centre Court in the first round at Wimbledon, has withdrawn from the women’s doubles tournament with a thigh injury.

Tan and Tamara Korpatsch were scheduled to play 15th-seeded Nadiia Kichenok and Raluca Olaru in the first round. They have been replaced in the draw by Valentini Grammatikopoulou and Peangtarn Plipuech.

Tan is scheduled to play No. 32 Sara Sorribes Tormo in the second round of the singles tournament on Thursday.

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1 p.m.

Top-ranked Iga Swiatek of Poland will host a charity tennis tournament next month to raise funds for children and teenagers impacted by the war in Ukraine.

The event will be held in Krakow on July 23 and will feature a mixed doubles exhibition match. Ukraine soccer great Andriy Shevchenko will be a special guest.

Elina Svitolina of Ukraine will serve as umpire for the event. They hope to sell at least 10,000 tickets.

Swiatek has been wearing a pin with the Ukrainian colors during her matches. More than 4 million refugees crossed into Poland after Russia invaded Ukraine in February. Poland is providing them with free shelter, social and medical care, education and job opportunities.

The All England Club banned players from Russia and Belarus from competing this year at Wimbledon because of the war.

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12:20 p.m.

Three-time Grand Slam champion Andy Murray will play alongside Rafael Nadal and Roger Federer at the Laver Cup in London in September.

Murray will be making his debut at the competition, which is played in a Europe vs. World format and does not award ATP ranking points.

This will be the fifth edition. It’s being held at the O2 Arena on Sept. 23-25. Team Europe is 4-0 so far.

Federer’s management company founded the competition.

Murray plays a second-round match at Wimbledon later Wednesday against John Isner of the United States.

The Scot said he’s “heard lots of good things and I’m excited to be teaming up with both Roger and Rafa for Team Europe.”

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11 a.m.

Top-seeded Novak Djokovic is back on Centre Court as the second round begins on Day 3 at Wimbledon.

The six-time Wimbledon champion will play 79th-ranked Thanasi Kokkinakis of Australia in the day’s opening match in the main stadium.

Then it’s the local favorites, with 10th-seeded Emma Raducanu facing Caroline Garcia of France, followed by two-time champion Andy Murray against 6-foot-10 John Isner of the United States.

French Open runner-up Casper Ruud is in action, as is 19-year-old Carlos Alcaraz of Spain. Ons Jabeur, Maria Sakkari and Angelique Kerber all have matches in the women’s draw.

Light rain fell in the morning with most of the day expected to be cloudy.

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